Non-parametric Estimation of Stochastic Differential Equations with Sparse Gaussian Processes

The application of Stochastic Differential Equations (SDEs) to the analysis of temporal data has attracted increasing attention, due to their ability to describe complex dynamics with physically interpretable equations. In this paper, we introduce a non-parametric method for estimating the drift and diffusion terms of SDEs from a densely observed discrete time series. The use of Gaussian processes as priors permits working directly in a function-space view and thus the inference takes place directly in this space. To cope with the computational complexity that requires the use of Gaussian processes, a sparse Gaussian process approximation is provided. This approximation permits the efficient computation of predictions for the drift and diffusion terms by using a distribution over a small subset of pseudo-samples. The proposed method has been validated using both simulated data and real data from economy and paleoclimatology. The application of the method to real data demonstrates its ability to capture the behaviour of complex systems

Differentiating signals to make biological sense – a guide through databases for MS-based non-targeted metabolomics

Metabolite identification is one of the most challenging steps in metabolomics studies and reflects one of the greatest bottlenecks in the entire workflow. The success of this step determines the success of the entire research, therefore the quality at which annotations are given requires special attention. A variety of tools and resources are available to aid metabolite identification or annotation, offering different and often complementary functionalities. In preparation for this article, almost 50 databases were reviewed, from which 17 were selected for discussion, chosen for their on-line ESI-MS functionality. The general characteristics and functions of each database is discussed in turn, considering the advantages and limitations of each along with recommendations for optimal use of each tool, as derived from experiences encountered at the Centre for Metabolomics and Bioanalysis (CEMBIO) in Madrid. These databases were evaluated considering their utility in non-targeted metabolomics, including aspects such as ID assignment, structural assignment and interpretation of results

Normas Internacionales de Información Financiera para Pequeñas y Medianas Entidades (NIIF para Pymes) : Análisis de la sección 21 provisiones y contingencias de las normas internacionales de información financiera para pequeñas y medianas entidades (NIIF para Pymes) implementadas en la empresa comercializadora San Agustín,S.A. para el año 2015

Nuestro trabajo de seminario presenta uno de los temas más actualizados de la contabilidad, a saber, Normas Internacionales de Información financieras para Pymes. Debido a que nuestro país una de las principales limitantes que tiene en lo que concierne al ejercicio de la contabilidad es el conocimiento de normas técnicas exactas que permitan el desarrollo completo y uniforme de la profesión, decidimos abordar el tema en general, y explicar de manera específica la sección 21: Provisiones y contingencias. Mediante un proceso de investigación documental, recopilamos información útil y de fuentes confiables, que permitirán el enriquecimiento del conocimiento además, se presentara un caso práctico el cual muestra los puntos principales teóricos así como también los efectos y beneficios de la correcta aplicación de dichas normas. Al finalizar todos los procedimientos establecidos, se logró cumplir con los objetivos los cuales implicaba destacar la importancia de las normas internacionales de información financiera para pequeñas y medianas entidades en lo particular la sección 21, provisiones y contingencias, además de proyectar una visión clara sobre la diferencia que muestra el uso de dicha normativa. Esperamos que este documento sea de gran utilidad, teniendo en cuenta lo importante que importante ampliar conocimientos, en todos los ámbitos de la profesión incluyendo la parte técnica como la legislación de la misma

Evaluation of cervical posture improvement of children with cerebral palsy after physical therapy based on head movements and serious games

Background: This paper presents the preliminary results of a novel rehabilitation therapy for cervical and trunk control of children with cerebral palsy (CP) based on serious videogames and physical exercise. Materials: The therapy is based on the use of the ENLAZA Interface, a head mouse based on inertial technology that will be used to control a set of serious videogames with movements of the head. Methods: Ten users with CP participated in the study. Whereas the control group (n=5) followed traditional therapies, the experimental group (n=5) complemented these therapies with a series of ten sessions of gaming with ENLAZA to exercise cervical flexion-extensions, rotations and inclinations in a controlled, engaging environment. Results: The ten work sessions yielded improvements in head and trunk control that were higher in the experimental group for Visual Analogue Scale, Goal Attainment Scaling and Trunk Control Measurement Scale (TCMS). Significant differences (27% vs. 2% of percentage improvement) were found between the experimental and control groups for TCMS (p<0.05). The kinematic assessment shows that there were some improvements in the active and the passive range of motion. However, no significant differences were found pre- and post-intervention. Conclusions:Physical therapy that combines serious games with traditional rehabilitation could allow children with CP to achieve larger function improvements in the trunk and cervical regions. However, given the limited scope of this trial (n=10) additional studies are needed to corroborate this hypothesis

A Low Cost Device for Monitoring the Urine Output of Critical Care Patients

In critical care units most of the patients’ physiological parameters are sensed by commercial monitoring devices. These devices can also supervise whether the values of the parameters lie within a pre-established range set by the clinician. The automation of the sensing and supervision tasks has discharged the healthcare staff of a considerable workload and avoids human errors, which are common in repetitive and monotonous tasks. Urine output is very likely the most relevant physiological parameter that has yet to be sensed or supervised automatically. This paper presents a low cost patent-pending device capable of sensing and supervising urine output. The device uses reed switches activated by a magnetic float in order to measure the amount of urine collected in two containers which are arranged in cascade. When either of the containers fills, it is emptied automatically using a siphon mechanism and urine begins to collect again. An electronic unit sends the state of the reed switches via Bluetooth to a PC that calculates the urine output from this information and supervises the achievement of therapeutic goals

An automatic critical care urine meter

Nowadays patients admitted to critical care units have most of their physiological parameters measured automatically by sophisticated commercial monitoring devices. More often than not, these devices supervise whether the values of the parameters they measure lie within a pre-established range, and issue warning of deviations from this range by triggering alarms. The automation of measuring and supervising tasks not only discharges the healthcare staff of a considerable workload but also avoids human errors in these repetitive and monotonous tasks. Arguably, the most relevant physiological parameter that is still measured and supervised manually by critical care unit staff is urine output (UO). In this paper we present a patent-pending device that provides continuous and accurate measurements of patient’s UO. The device uses capacitive sensors to take continuous measurements of the height of the column of liquid accumulated in two chambers that make up a plastic container. The first chamber, where the urine inputs, has a small volume. Once it has been filled it overflows into a second bigger chamber. The first chamber provides accurate UO measures of patients whose UO has to be closely supervised, while the second one avoids the need for frequent interventions by the nursing staff to empty the containe

Sistema informático para el control de la atención de clientes de la empresa Home Data Systen SAC

El presente proyecto abarca el desarrollo y la implementación de un sistema informático en el control de la atención de los clientes así como de los técnicos, dándose la aplicación en el área de soporte técnico de la empresa “Home Data Systen SAC”. El principal objetivo de esta investigación es determinar la influencia de un sistema informático para el control de la atención de clientes de la empresa “Home Data Systen SAC”, para así tener sistematizado el proceso de todas las reparaciones de los equipos de cómputo como también la persona que realizo dicho trabajo todo ello para mejorar el grado de cumplimiento y el grado de eficacia de dicho proceso, de esta manera minimizar demoras y tener un mejor control en la atención de clientes, ayudando a realizar sus tareas de una manera cumplida, eficaz y ordenada. Segúnpeste objetivo sepplanteó el desarrollo de un sistemapinformático que controle los clientes, los equipos de cómputo, los equipos de cómputo asignado a cada trabajador, el grado de cumplimiento y eficacia en realizar las atenciones de los clientes (equipos de cómputo), utilizando parapsu diseño la metodología RUP por ser la máspacorde y utilizada para elpanálisis, implementaciónpy documentación de sistemas en la actualidad, además la herramienta de desarrollo o lenguaje de programación utilizada es PHP y el gestor de base de datos MYSQL . La arquitectura del sistema se basó en el patrón de desarrollo MVC (Modelo-Vista-Controlador). Seppuede concluirpque el sistema informático influyepde manera positiva en el control de la atención de clientes, equipos de cómputos y trabajadores, teniendo un proceso automatizado que ayuda a una mejor organización delpcontrol e integración de lapinformación y a lapvez, mayorpfluidez en laspactividades administrativas de la empresa “Home Data Systen SAC”

Error analysis in the determination of the electron microscopical contrast transfer function parameters from experimental power Spectra

<p>Abstract</p> <p>Background</p> <p>The transmission electron microscope is used to acquire structural information of macromolecular complexes. However, as any other imaging device, it introduces optical aberrations that must be corrected if high-resolution structural information is to be obtained. The set of all aberrations are usually modeled in Fourier space by the so-called Contrast Transfer Function (CTF). Before correcting for the CTF, we must first estimate it from the electron micrographs. This is usually done by estimating a number of parameters specifying a theoretical model of the CTF. This estimation is performed by minimizing some error measure between the theoretical Power Spectrum Density (PSD) and the experimentally observed PSD. The high noise present in the micrographs, the possible local minima of the error function for estimating the CTF parameters, and the cross-talking between CTF parameters may cause errors in the estimated CTF parameters.</p> <p>Results</p> <p>In this paper, we explore the effect of these estimation errors on the theoretical CTF. For the CTF model proposed in <abbrgrp><abbr bid="B1">1</abbr></abbrgrp> we show which are the most sensitive CTF parameters as well as the most sensitive background parameters. Moreover, we provide a methodology to reveal the internal structure of the CTF model (which parameters influence in which parameters) and to estimate the accuracy of each model parameter. Finally, we explore the effect of the variability in the detection of the CTF for CTF phase and amplitude correction.</p> <p>Conclusion</p> <p>We show that the estimation errors for the CTF detection methodology proposed in <abbrgrp><abbr bid="B1">1</abbr></abbrgrp> does not show a significant deterioration of the CTF correction capabilities of subsequent algorithms. All together, the methodology described in this paper constitutes a powerful tool for the quantitative analysis of CTF models that can be applied to other models different from the one analyzed here.</p

PENGARUH FINANCIAL DISTRESS, LEVERAGE, KESEMPATAN BERTUMBUH, DAN PERTUMBUHAN PERUSAHAAN TERHADAP KONSERVATISME AKUNTANSI PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA TAHUN 2012-2014

The objectives of this research are to examine (1) the effect of financial distress, leverage, growth opportunities, and company growth simultaneously on accounting conservatism, and (2) the effect of financial distress, leverage, growth opportunities, and company growth partially on accounting conservatism.Purposive sampling method is used in this research to determine the sample. The sample of this research is manufacturing company sub-sector consumption listed in Indonesia Stock Exchange during 2012 until 2014. The analysis method used in the research is multiple linear regressions.The result of this research are (1) financial distress, leverage, growth opportunities, and company growth simultaneously effect the accounting conservatism, (2) financial distress, leverage, and company growth partially have not effect the accounting conservatism and, (3) growth opportunity have an effect on the accounting conservatismKeywords: accounting conservatism, financial distress, leverage, growth opportunities, and company growthBanda Ace